Protein Details: Two pore calcium channel protein 1B

Protein ID

ICDB_Pro_1141

Protein Name

Two pore calcium channel protein 1B

Gene Name

TPC1B

Organism

Nicotiana tabacum (Common tobacco)

Length

735 amino acids

AlphaFoldDB

AF-Q75VR0-F1-model_v4.pdb

Function

Functions as a voltage-gated inward-rectifying Ca(2+) channel (VDCC) across the plasma membrane that mediates sucrose-induced Ca(2+) influx in autotrophically grown leaf cells. Acts as the major ROS-responsive Ca(2+) channel and is the possible target of Al-dependent inhibition. Plays a regulatory role in defense responses.

Sequence

MEEYLLPGESSNSCRTRRRSGSIFDRRDAIAHGSAYQKAAALVDLAEDGIGLPEEILEGASFEKAAELYFMFTRFDFLWSLNYLALVVLNFFEKPLWCSKHLAESCNNRDYYYLGELPFLTGAESLIFEGVTLLLLIIHILFPISYEGFNLYWRSLLNRLKVILLLILVADIVVYILLPADFYYLPFRIAPYLRVVFFILNIRELRDSFFILAGMLGTYLNVVALSALFLLFSSWLAYVFFEDTRQGKTTFTSYGTTLYQMFVLFTTSNNPDVWIPAYKDSRWYCLFFVLYVLLGVYFVTNLILAVVYDSFKSELVKQVADKDRLRLRTLKKAFSLIDEANNGLLNEKQCTLLFEELNKYRTLPKISGDDFKSIFNELDDTGDFKINLEEFADLCSAIGLRFQKEDSLPIFEACPNFYHSPASEKLRGFIRGATFEYIIVFVLLVNLVAVIIETTLDIQNNSGQTFWQKVEFTFGWLYVIEMALKVYTYGFENYWRDGQNRFDFIVTWVIVIGETTTFVAPDDLTFLSNGEWIRYLLIARMLRLIRLLMHVERYRAFVATFLTLIPSLMPYLGTIFCILCFYCSLGLQIFGGIVNTGNPNLAQTDLAGNDYLLFNFNDYPNGMVTLFNILVMGNWQVWMQSYKELTGTSWTYAYFVSFYLISVLWLLNLIVAFVLEAFQAEMDLEASARCVDGDDKEAKRERRRNVGTKTRSQRVDFLLHHMLRSELTECSNDNP

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1016/j.bbrc.2004.03.114; 10.1016/j.bbrc.2004.09.015; 10.1016/j.bbrc.2005.05.030

RefSeq

NP_001312977.1;